NXTGNT was founded in 2008 to create a rich and unique substrate for groundbreaking research, development and valorization at Ghent University. The main goal of NXTGNT is the establishment of a reference center and core facilty for next generation sequencing (NGS), (epi-)genome and transcriptome analysis at Ghent University. NXTGNT established a unique service platform by the integration of a state-of-the-art NGS library preparation facility with several sequencing platforms and a strong expertise in -omics data-analysis (bioinformatics).
Using massively parallel sequencing the genome sequence can be accurately determined. Depending on your setting and interest the whole genome can be sequenced (even starting from a very limited amount of DNA) or specific genes or regions (e.g. exome sequencing) can be targeted.
Transcriptomics (or expression profiling) is the study of the complete set of RNA transcripts that are produced by specific cells or tissues under specific circumstances. Messenger RNAs (mRNA), micro RNAs (miRNA), long non-coding RNAs (lncRNA), etc can be sequenced and quantified, allowing differential gene expression analysis.
Epigenetics research seeks to describe dynamic alterations in the transcriptional potential of a cell. The main epigenetic mechanisms are DNA methylation, histone modification, DNA accessibility and non-coding RNA-associated gene silencing. NXTGNT has all the tools in house to analyse these epigenetic mechanism in an integrated analysis.
NXTGNT can help you with your sequencing data analysis with a team of high-skilled experts. We perform data analysis starting from raw sequencing reads, working towards publication-ready results: Statistics, visualization, PCA analysis, Gene-Set Enrichment Analysis, pathway analysis, etc. Feel free to contact us regarding any question.
We provide all single cell and linked-reads sequencing solutions offered by the 10X Genomics Chromium System & GemCode Technology
Molecular insights, connecting physicians and their patients to the latest treatment approaches through pharmacogenetics, making precision medicine a reality.
Oxford nanopore sequences unamplified DNA and RNA, eliminating the need for amplification steps (and the resulting quantitative and qualitative amplification bias). Long reads up to 100 kbp with direct detection of 5-methylcytosines in DNA and N6-methyladenines in RNA provide tremendous advantages in de novo assembly, detection of large structural variants, RNA isomforms, etc.
Our PALM MicroBeam is designed to give you advanced laser microdissection capabilities for subsequent DNA, and RNA analysis — whether from archive material or live cells. Applicable to cryosections, and FFPE tissue, even from standard glass slides.
NXTGNT is specialized in low input samples such as single cell samples, FFPE samples, and LCM samples
Faculty of Pharmaceutical Sciences
When entering the Ghent University Faculty of Pharmaceutical Sciences through the main entrance, elevators will be located in front of you. NXTGNT is situated on the third floor. When exiting the elevators, NXTGNT is located at your right-hand side.
Call: +32 9 264 80 59